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Glyburide is an oral diabetes medicine that helps control blood sugar levels.

No exact dosage relationship exists between MICRONASE and the other oral hypoglycemic agentsAlthough patients may be transferred from the maximum dose of other sulfonylureasthe maximum starting dose of 5 mg of MICRONASE Tablets should be observedA maintenance dose of 5 mg of MICRONASE Tablets provides approximately the same degree of blood glucose control as 250 to 375 mg chlorpropamide250 to 375 mg tolazamide500 to 750 mg acetohexamideor 1000 to 1500 mg tolbutamide.

Studies in rats at doses up to 300 mg/kg/day for 18 months showed no carcinogenic effectsGlyburide is nonmutagenic when studied in the Salmonella microsome testAmes testand in the DNA damage/alkaline elution assayNo drug related effects were noted in any of the criteria evaluated in the two year oncogenicity study of glyburide in mice.

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