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The patients in studies had varying degrees of EDOne-third to one-half of the subjects in these studies reported successful intercourse at least once during a 4-weektreatment-free run-in period.
Blood pressure was measured after administration of VIAGRA at the same times as those specified for the first doxazosin studyThere were two subjects who had a standing SBP of 30mmHg following VIAGRA 50 mg and one subject with a decrease from baseline in standing systolic BP30 mmHg following both VIAGRA 50 mg and placeboThere were no severe adverse events potentially related to blood pressure and no episodes of syncope reported in this study.
VIAGRA is rapidly absorbedMaximum observed plasma concentrations are reached within 30 to 120 minutesmedian 60 minutesof oral dosing in the fasted stateWhen VIAGRA is taken with a high fat mealthe rate of absorption is reducedwith a mean delay in Tmax of 60 minutes and a mean reduction in Cmax of 29The mean steady state volume of distributionVssfor sildenafil is 105 Lindicating distribution into the tissuesSildenafil and its major circulating N-desmethyl metabolite are both approximately 96bound to plasma proteinsProtein binding is independent of total drug concentrations.
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